Durston and Madsen guide Derbyshire home
Derbyshire 194 for 4 beat Sussex 193 for 8 by six wickets
Derbyshire bounced back from last week's Clydesdale Bank 40 defeat to Holland as they beat Sussex by six wickets with 14 balls to spare at windswept Derby.
Sussex lost seven for 56 on a slow pitch after winning the toss and only an unbroken ninth-wicket stand of 62 in 9.3 overs between Rana Naved-ul-Hasan and Will Beer lifted them to 193 for 8.
Wes Durston (70 from 90 balls) and Wayne Madsen (48 not out from 57) then steered Derbyshire to their 194 target against a Sussex attack that was minus England all-rounder Luke Wright, who could not bowl because of an injury.
Wright had earlier scored 23 as the Sharks started well until a series of rash strokes sparked a collapse that saw them crash from 75 for 1 to 131 for 8 in 18 overs.
Ed Joyce hit five fours in his 37 which came off 40 balls before he came down the pitch at medium pacer Greg Smith and was smartly stumped by Luke Sutton.
Wright failed to clear mid-off in Smith's next over and the innings went into sharp decline against the spinners, who conceded only 66 runs in 20 overs.
Joe Gatting was stumped giving Chesney Hughes the charge, Andy Hodd edged a big drive and Murray Goodwin skied Azeem Rafiq to deep midwicket.
Durston found some turn to beat Naved Arif's defensive push and and when Will Adkin drilled Hughes to long off, the Sharks were in danger of falling well short of a competitive score.
But Rana and Beer played sensibly in the closing stages of the innings and the total was boosted by a Steffan Jones over which cost 17, including five wides.
The Falcons got off to a flier with Usman Khawaja and Hughes taking 50 from the opening nine overs before the Australian was caught behind cutting at Adkin.
A direct hit from cover by Goodwin ran out Hughes for 30 but Durston and Smith put the home side back on track, with Durston driving Monty Panesar over long on for the game's only six.
But Smith needlessly swept Panesar to deep square leg in the 17th over and Sussex would have been back in the hunt had Hodd not fumbled a stumping chance when Durston was on 39.
Durston and Madsen shared a stand of 89 in 19 overs and, although Durston was run out in the 36th over with eight runs needed, it was too late for Sussex who were well beaten in their first Group A game.