Both bowlers impressed against Somerset at Taunton, Amir taking 3 for 36 in the first innings with some dangerous swing at good pace while Yasir enjoyed a lengthy bowl in the second innings as he finished with 4 for 107.
Rahat Ali has also been left out as Pakistan bring in Wahab Riaz, Imran Khan and Zulfiqar Babar.
The batting, though, remains unchanged which, barring injuries, confirms the top-order line-up for the opening Test. Most of the batsmen spent decent time in the middle against Somerset, although Mohammad Hafeez (20 and 10), captain Misbah-ul-Haq (0 and 19) and wicketkeeper Sarfraz Ahmed will hope for a more productive outing at Hove.
"We had a pretty decent outing against Somerset. I would expect everyone shall maintain and improve on standards on display at Taunton in batting, bowling and fielding," Mickey Arthur, the head coach, said. "We have to keep up with the benchmarks we have achieved so far, with the same intensity. Slacking off at any point would not be acceptable".