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Hampshire 246 (Gubbins 101*, Fuller 55, Hasan 5-45) and 103 for 3 (Gubbins 40*, Dawson 20*, Anderson 2-17) lead Lancashire 240 (Bailey 59, Salt 55, Barker 5-67) by 109 runs
Keith Barker claimed his second LV= Insurance County Championship five-wicket haul of the season as Hampshire and Lancashire continued their close-fought encounter.
Left-arm fast bowler Barker is the equal leading wicket-taker in Division One so far this season with 20 scalps, with his 5 for 67 adding to his impressive start to the campaign.
Nick Gubbins lead Hampshire's evening lead builder, while James Anderson added two more wickets to his career tally - with Hampshire closing on 103 for 3, the lead growing to 109.
The county champions tend to be the teams who take 20 wickets the easiest each match, and therefore have the best bowling attack. This is the main reason Hampshire and Lancashire are considered to be this year's main challengers.
Anderson, Hasan Ali and Tom Bailey vs Kyle Abbott, Muhammad Abbas and Keith Barker, or in terms of first class wickets 1,547 vs 1,515, back that up. Against other attacks the par on this pitch might be close to 350, rather than 250, such has been the relentlessness of accurate and skilful fast bowling.
The helpful morning conditions which had reduced Hampshire to 40 for 5 on the first morning returned to see Lancashire lose six wickets in little over an hour on day two. Nightwatchman Danny Lamb pushed forward to third slip, Josh Bohannon and Dane Vilas were undone by some extra bounce by the impressive Barker and George Balderson nicked behind having been done on the angle by Abbott.
Steven Croft attempted to cut with a flourish but instead nailed into the slip cordon and Rob Jones jerked behind - Lancashire 105 for 7, with all seven being caught behind the wicket. Hampshire's lead would have been closer to three figures had Joe Weatherley held onto misjudgements from Bailey and Salt when there were in single figures.
The duo put on 94 with risk-free cricket to as the ball started to age. Bailey dominated the offside with boundaries, while Salt milked either side of the wicket with intelligent running - half-centuries coming in 70 and 68 balls respectively.
The stand ended when Bailey strode forward to edge to third slip, but Hasan joined the tail-end fun to take the scores to almost parity with a smart 19 - with Barker eventually ending things by bowling a slogging Salt and having Hasan picking out long-on.
First time around, Anderson was forced to wait until his 18th delivery before taking Ian Holland's outside edge. He needed half the deliveries to persuade Weatherley to prod a wobble ball to Rob Jones' safe hands at third slip. Holland followed soon after lbw to Hasan.
James Vince and Gubbins batted their way out of another sticky situation with their glorious shot-making, putting on 58 carefree runs before the former was adjudged leg before to Anderson - a decision that left Vince seething.
Gubbins, who survived a tight lbw appeal, was joined by Liam Dawson and the pair put on an unbeaten 33 under the floodlights before play finished five over short due to bad light.
Nick Gubbins back on track after underlining credentials with twin tons
The move to Hampshire has revitalised Gubbins' career after he rode the highs and lows at Middlesex
Rain wipes out final day as Lancashire, Hampshire share spoils
No play possible in finely poised contest at Ageas Bowl
Nick Gubbins' twin tons give Hampshire hefty lead over Lancashire
Batter follows his innings-rescuing 101* with an effortless 130
Keith Barker claims five as Hampshire edge ahead in duel with Lancashire
James Anderson has two second-innings wickets so far to help contain hosts' lead