Left-arm spinner Rebecca Grundy has been ruled out of England's summer schedule against India and South Africa with a groin injury. England have called up three replacements, Stephanie Butler, Sonia Odedra and Danielle Wyatt, to replace Grundy across the three formats.
Grundy, who has played six T20s since making her debut during the World T20, is one of the young spinners being brought on in the absence of Holly Colvin and Laura Marsh. She suffered a femoral stress reaction in her left groin and is to undergo a rehabilitation programme.
Buttler, 19, who bowls offspin for Staffordshire, comes in to the squad for the India Test, which begins on Wednesday. Medium-pacer Odedra was already in the Test squad and will stay on for three ODIs, while Wyatt, who has 82 caps, returns for the T20s against South Africa next month.
"This is very disappointing news for Becky and it is clearly unfortunate to lose her from the squad before our summer internationals against India and South Africa have even got underway," Paul Shaw, the head of performance, said. "She will now undergo the necessary treatment and rehabilitation to get back to full fitness as quickly as possible.
"We are in a very strong position to be able call-up three very talented players to replace Becky across seven matches that we have this summer.
"Young Stephanie Butler from Staffordshire has been included in an England women's squad for the first time, after enjoying a good season with the ball in county cricket and also impressing with her performances for the England Women's Academy in Sri Lanka over the winter. I'm sure she will learn a lot from the experience.
"I'm also looking forward to working with Sonia Odedra during the Kia Women's Test and Royal London ODI series, and to welcoming Danielle Wyatt back into the fold for the NatWest T20Is against South Africa in September."
Despite becoming full-time professionals at the start of the summer, a ground-breaking move that was followed by the first standalone sponsorship deal for the women's team, England have not played since the World T20, where they lost to Australia in the final. The Test against India will take place at Wormsley, followed by two ODIs in Scarborough and one at Lord's.
England squads: Charlotte Edwards (capt), Heather Knight, Tammy Beaumont, Katherine Brunt (ODI and T20), Stephanie Butler (Test only), Kathryn Cross (Test and ODI), Natasha Farrant (T20 only), Lydia Greenway, Jenny Gunn, Danielle Hazell, Amy Jones, Sonia Odedra (Test and ODI), Natalie Sciver, Anya Shrubsole, Sarah Taylor (wkt), Lauren Winfield, Danielle Wyatt (T20 only)