Graeme Smith is unlikely to play a part in the fifth and final ODI against Pakistan in Benoni on Sunday due a recurrence of an ankle injury during South Africa's defeat in the fourth ODI in Durban. Smith was unable to field for a majority of Pakistan's innings due to the injury.
"Graeme's chronic left ankle problem has surfaced again during this ODI series," Dr Mohammed Moosajee, South Africa's team manager, said. "We have been trying to manage him but unfortunately the impingement syndrome slowed him down today and he is quite symptomatic.
"As things stand, he is unlikely to play in the last ODI but we will make a final decision tomorrow (Friday). He has had surgery on this ankle a while ago and I think the load and the volume of cricket for the year, and particularly during this ODI series, has troubled him."
Smith was bowled by Junaid Khan for 12 in Pakistan's three-wicket win that levelled the series 2-2.
The selectors will decide on Friday, whether or not to name a replacement.