Kirsten, the former South Africa opener, coached India to World Cup victory in 2011 and then oversaw South Africa's rise to the No. 1 Test ranking. He has had extensive experience in the world of franchise T20, working with Bangalore Royal Challengers in the IPL and Hobart Hurricanes in the Big Bash.
"To be involved in English and Welsh cricket from a coaching perspective is something that I have never done," Kirsten said. "It's great to be given that opportunity and to come to Cardiff.
"This is a new format that I am sure will grow and grow. The real win is that it will grab the attention of families and expose the game of cricket to as many environments and communities as possible."
Mott knows Cardiff well from his time in charge of Glamorgan between 2011 and 2013. He has previously coached in the Sheffield Shield, and took charge of the Australia women's team in 2015, leading them to the title at last year's T20 World Cup, and overseeing their successful recent defence of the Ashes in the UK.
"Cardiff is a special place for me and my family and that was a big part in my decision to return," Mott said.
"I've got no doubt The Hundred will be a success for the women's game. I've got a young son who is a Sydney Sixers fan and he doesn't see gender - he just sees the team. The Hundred will provide that sort of platform in England and Wales and I can't speak highly enough of what that can mean for the game."