Mark Wagh again showed his liking for the Durham attack as he thrashed 112 and allowed Warwickshire to set their hosts a target of 404 at Chester-le-Street.
In seven overs Durham reached 12 without loss and Warwickshire hope Vasbert Drakes will be fit to bowl today after resting the knee injury he suffered on Friday evening.
The declaration came just before 6pm on 324 for six with Dougie Brown on 67 not out, made off 64 balls, after Wagh and Dominic Ostler had softened up Durham's depleted attack.
Simon Brown, who also suffered a knee injury while bowling on Friday, took the field only to make two not out in the morning as Durham's remaining three wickets went down for 23 runs and they were all out for 231.
Wagh and Ostler put on 99 in 24 overs for the fourth wicket as Wagh completed his second hundred of the season, both made against Durham.
He reached 50 off 99 balls but needed only 57 more deliveries to complete his hundred, racing to the target with a six over mid-wicket in an over from Nicky Phillips off which he took 16 runs.
He hit two other sixes plus 16 fours before edging an attempted cut off Michael Gough.
Ostler then put on 86 in 15 overs with Brown before falling 14 short of his second century of the match when he sliced a drive to point. He had ten fours and two sixes in his 126-ball knock.
Brown completed the onslaught by smashing successive balls from Phillips for four, six, four just before the declaration.
Warwickshire vs Durham
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England Domestic Season