Largest margins by Innings, runs & wickets for Rachael Heyhoe Flint Trophy, 2022
By runs
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 139 runs | 0 | 261 | 28.5 | 50.0 | v Sunrisers | Worcester | 17 Sep 2022 | Other OD | |
| 133 runs | 0 | 307 | 38.4 | 50.0 | v SE Stars | Hove | 9 Jul 2022 | Other OD | |
| 112 runs | 0 | 282 | 38.4 | 50.0 | v Lightning | Leicester | 17 Sep 2022 | Other OD | |
| 104 runs | 0 | 335 | 45.4 | 50.0 | v Storm | Taunton | 11 Sep 2022 | Other OD | |
| 80 runs | 0 | 282 | 41.4 | 50.0 | v Sunrisers | Beckenham | 2 Jul 2022 | Other OD | |
| 75 runs | 0 | 242 | 34.2 | 34.2 | v Lightning | Loughborough | 2 Jul 2022 | Other OD | |
| 70 runs | 0 | 231 | 41.0 | 50.0 | v Sunrisers | Chelmsford | 11 Sep 2022 | Other OD | |
| 66 runs | 0 | 295 | 44.0 | 50.0 | v Lightning | Derby | 16 Jul 2022 | Other OD | |
| 59 runs | 0 | 255 | 50.0 | 50.0 | v Sparks | Beckenham | 11 Sep 2022 | Other OD | |
| 52 runs | 0 | 199 | 40.1 | 50.0 | v Thunder | Southport | 16 Jul 2022 | Other OD | |
| 36 runs | 0 | 284 | 48.0 | 50.0 | v Storm | Cheltenham | 23 Jul 2022 | Other OD | |
| 28 runs | 0 | 220 | 41.4 | 43.0 | v Sparks | Manchester | 23 Jul 2022 | Other OD | |
| 22 runs | 0 | 207 | 50.0 | 50.0 | v Storm | Bristol | 9 Jul 2022 | Other OD | |
| 11 runs | 0 | 234 | 50.0 | 50.0 | v Sunrisers | Southampton | 23 Jul 2022 | Other OD | |
| 6 runs | 0 | 195 | 45.2 | 50.0 | v Sunrisers | Leeds | 9 Jul 2022 | Other OD | |
| 2 runs | 0 | 216 | 50.0 | 50.0 | v Vipers | Lord's | 25 Sep 2022 | Other OD |
By wickets
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 6 wickets | 46 | 236 | 42.2 | 50.0 | v Thunder | Sale | 3 Jul 2022 | Other OD | |
| 6 wickets | 96 | 140 | 34.0 | 50.0 | v SE Stars | Beckenham | 21 Sep 2022 | Other OD | |
| 5 wickets | 64 | 215 | 39.2 | 50.0 | v Sparks | Worcester | 16 Jul 2022 | Other OD | |
| 4 wickets | 18 | 204 | 47.0 | 50.0 | v Thunder | Southampton | 11 Sep 2022 | Other OD | |
| 4 wickets | 42 | 227 | 43.0 | 50.0 | v Vipers | Leeds | 17 Sep 2022 | Other OD | |
| 2 wickets | 21 | 239 | 44.3 | 48.0 | v Thunder | Manchester | 18 Sep 2022 | Other OD |
By balls remaining in the second innings
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 6 wickets | 96 | 140 | 34.0 | 50.0 | v SE Stars | Beckenham | 21 Sep 2022 | Other OD | |
| 5 wickets | 64 | 215 | 39.2 | 50.0 | v Sparks | Worcester | 16 Jul 2022 | Other OD | |
| 6 wickets | 46 | 236 | 42.2 | 50.0 | v Thunder | Sale | 3 Jul 2022 | Other OD | |
| 4 wickets | 42 | 227 | 43.0 | 50.0 | v Vipers | Leeds | 17 Sep 2022 | Other OD | |
| 2 wickets | 21 | 239 | 44.3 | 48.0 | v Thunder | Manchester | 18 Sep 2022 | Other OD | |
| 4 wickets | 18 | 204 | 47.0 | 50.0 | v Thunder | Southampton | 11 Sep 2022 | Other OD | |
| 3 wickets | 6 | 255 | 49.0 | 50.0 | v Sunrisers | Chelmsford | 16 Jul 2022 | Other OD | |
| 5 wickets | 5 | 239 | 49.1 | 50.0 | v Thunder | Loughborough | 9 Jul 2022 | Other OD | |
| 7 wickets | 2 | 70 | 9.4 | 10.0 | v Sparks | Birmingham | 2 Jul 2022 | Other OD | |
| 1 wicket | 2 | 200 | 49.4 | 50.0 | v Lightning | Chester-le-Street | 23 Jul 2022 | Other OD |
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