Kyle Abbott found movement with the new ball and bowled Australia's openers inside three overs Associated Press
Wristspinner Tabraiz Shamsi then dismissed Steven Smith and Travis Head to compound Australia's woes AFP
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Matthew Wade, however, counterattacked his way to a half-century Associated Press
Mitchell Marsh, meanwhile, played sensibly and made a fifty of his own before becoming Abbott's third victim. Australia were 111 for 6 AFP
Abbott also accounted for Adam Zampa en route to figures of 4 for 40 AFP
Aaron Phangiso removed Wade and Scott Boland in the 37th over to dismiss Australia for 167 AFP
Chris Tremain gave Australia hope by reducing South Africa to 29 for 2 in 6.1 overs Getty Images
Faf du Plessis and JP Duminy then put the hosts back in control with a 56-run partnership for the third wicket Getty Images
The stand ended when Zampa had Duminy caught by Marsh for 25 in the 20th over AFP
Du Plessis, however, went on to score his second fifty-plus score of the series as South Africa wrapped up a six-wicket win to go 4-0 up Associated Press