Largest margins in FC+LA+T20s by Innings, runs & wickets for Melbourne Stars vs Sydney Sixers
By runs
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 152 runs | 0 | 214 | 11.1 | 20.0 | v Stars | Sydney | 5 Dec 2021 | Twenty20 | |
| 94 runs | 0 | 169 | 13.4 | 20.0 | v Sixers | Melbourne | 10 Feb 2019 | Twenty20 | |
| 77 runs | 0 | 201 | 20.0 | 20.0 | v Sixers | Sydney | 29 Dec 2013 | Twenty20 | |
| 44 runs | 0 | 220 | 20.0 | 20.0 | v Sixers | Melbourne | 12 Jan 2020 | Twenty20 | |
| 43 runs | 0 | 143 | 18.0 | 20.0 | v Stars | Melbourne | 31 Jan 2020 | Twenty20 | |
| 21 runs | 0 | 178 | 20.0 | 20.0 | v Sixers | Melbourne | 21 Dec 2012 | Twenty20 | |
| 21 runs | 0 | 147 | 14.0 | 14.0 | v Stars | Sydney | 20 Jan 2020 | Twenty20 | |
| 19 runs | 0 | 117 | 12.0 | 12.0 | v Stars | Sydney | 8 Feb 2020 | Twenty20 | |
| 16 runs | 0 | 157 | 20.0 | 20.0 | v Sixers | Melbourne | 9 Jan 2025 | Twenty20 | |
| 2 runs | 0 | 167 | 20.0 | 20.0 | v Stars | Sydney | 27 Dec 2011 | Twenty20 |
By wickets
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 8 wickets | 29 | 129 | 15.1 | 20.0 | v Stars | Melbourne | 16 Jan 2018 | Twenty20 | |
| 8 wickets | 11 | 195 | 18.1 | 20.0 | v Stars | Sydney | 26 Dec 2024 | Twenty20 | |
| 7 wickets | 11 | 157 | 18.1 | 20.0 | v Stars | Melbourne | 6 Jan 2024 | Twenty20 | |
| 5 wickets | 15 | 190 | 17.3 | 20.0 | v Stars | Sydney | 23 Jan 2018 | Twenty20 | |
| 5 wickets | 31 | 131 | 14.5 | 20.0 | v Sixers | Sydney | 27 Dec 2018 | Twenty20 |
By balls remaining in the second innings
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 5 wickets | 31 | 131 | 14.5 | 20.0 | v Sixers | Sydney | 27 Dec 2018 | Twenty20 | |
| 8 wickets | 29 | 129 | 15.1 | 20.0 | v Stars | Melbourne | 16 Jan 2018 | Twenty20 | |
| 5 wickets | 15 | 190 | 17.3 | 20.0 | v Stars | Sydney | 23 Jan 2018 | Twenty20 | |
| 7 wickets | 11 | 157 | 18.1 | 20.0 | v Stars | Melbourne | 6 Jan 2024 | Twenty20 | |
| 8 wickets | 11 | 195 | 18.1 | 20.0 | v Stars | Sydney | 26 Dec 2024 | Twenty20 | |
| 5 wickets | 8 | 140 | 18.4 | 20.0 | v Sixers | Sydney | 27 Dec 2015 | Twenty20 | |
| 3 wickets | 6 | 157 | 19.0 | 20.0 | v Stars | Melbourne | 21 Jan 2017 | Twenty20 | |
| 7 wickets | 5 | 151 | 19.1 | 20.0 | v Stars | Sydney | 26 Dec 2022 | Twenty20 | |
| 4 wickets | 3 | 155 | 19.3 | 20.0 | v Sixers | Sydney | 26 Dec 2023 | Twenty20 | |
| 7 wickets | 2 | 178 | 19.4 | 20.0 | v Stars | Melbourne | 15 Dec 2021 | Twenty20 | |
| 1 wicket | 1 | 194 | 19.5 | 20.0 | v Stars | Carrara | 26 Dec 2020 | Twenty20 | |
| 5 wickets | 1 | 178 | 19.5 | 20.0 | v Stars | Melbourne | 26 Jan 2021 | Twenty20 | |
| 6 wickets | 1 | 174 | 19.5 | 20.0 | v Stars | Melbourne | 6 Jan 2023 | Twenty20 |
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