Largest margins by Guyana in T20s by Innings, runs & wickets
By runs
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 42 runs | 0 | 109 | 17.2 | 20.0 | v Barbados | Port of Spain | 10 Jan 2013 | Twenty20 | |
| 14 runs | 0 | 157 | 20.0 | 20.0 | v Leeward Is | Gros Islet | 17 Jan 2013 | Twenty20 | |
| 10 runs | 0 | 147 | 20.0 | 20.0 | v Antg & Barb | Coolidge | 17 Feb 2008 | Twenty20 | |
| 4 runs | 0 | 176 | 18.5 | 19.0 | v Trinidad & T | Port of Spain | 30 Jul 2010 | Twenty20 | |
| 1 run | 0 | 113 | 20.0 | 20.0 | v Somerset | North Sound | 12 Jan 2011 | Twenty20 |
By wickets
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 9 wickets | 52 | 63 | 11.2 | 20.0 | v Bermuda | Coolidge | 10 Feb 2008 | Twenty20 | |
| 8 wickets | 21 | 116 | 16.3 | 20.0 | v Montserrat | Coolidge | 21 Jul 2006 | Twenty20 | |
| 8 wickets | 18 | 144 | 17.0 | 20.0 | v Canada | Bridgetown | 17 Jan 2012 | Twenty20 | |
| 6 wickets | 10 | 159 | 18.2 | 20.0 | v Grenada | Coolidge | 10 Aug 2006 | Twenty20 |
By balls remaining in the second innings
Winner | Margin | Balls Rem | Target | Overs | Max | Opposition | Ground | Match Date | Scorecard |
| 9 wickets | 52 | 63 | 11.2 | 20.0 | v Bermuda | Coolidge | 10 Feb 2008 | Twenty20 | |
| 8 wickets | 21 | 116 | 16.3 | 20.0 | v Montserrat | Coolidge | 21 Jul 2006 | Twenty20 | |
| 8 wickets | 18 | 144 | 17.0 | 20.0 | v Canada | Bridgetown | 17 Jan 2012 | Twenty20 | |
| 6 wickets | 10 | 159 | 18.2 | 20.0 | v Grenada | Coolidge | 10 Aug 2006 | Twenty20 | |
| 6 wickets | 8 | 184 | 18.4 | 20.0 | v Jamaica | Gros Islet | 19 Jan 2013 | Twenty20 | |
| 3 wickets | 6 | 164 | 19.0 | 20.0 | v Jamaica | Coolidge | 29 Jul 2006 | Twenty20 | |
| 5 wickets | 4 | 158 | 19.2 | 20.0 | v Windward Is | Bridgetown | 23 Jul 2010 | Twenty20 | |
| 4 wickets | 4 | 143 | 19.2 | 20.0 | v Comb C&C | Bridgetown | 25 Jul 2010 | Twenty20 | |
| 5 wickets | 4 | 135 | 19.2 | 20.0 | v Leeward Is | North Sound | 9 Jan 2012 | Twenty20 | |
| 2 wickets | 2 | 176 | 19.4 | 20.0 | v Comb C&C | North Sound | 14 Jan 2011 | Twenty20 | |
| 5 wickets | 1 | 176 | 19.5 | 20.0 | v Trinidad & T | Coolidge | 13 Aug 2006 | Twenty20 | |
| 1 wicket | 1 | 135 | 19.5 | 20.0 | v Barbados | Port of Spain | 31 Jul 2010 | Twenty20 | |
| 2 wickets | 0 | 160 | 20.0 | 20.0 | v Comb C&C | Port of Spain | 7 Jan 2013 | Twenty20 | |
| 4 wickets | 0 | 118 | 20.0 | 20.0 | v Windward Is | Gros Islet | 18 Jan 2013 | Twenty20 |
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