Hameed and Samiullah handed call-ups
Hameed, 28, has been ignored by the selectors since June 2005 when he played during the tour of West Indies but his recall had been tipped after Pakistan's continued problems over finding a successful opening partnership.
Over the last two years they tried 15 different combinations at the top of the order. Hameed will fight for opening berth with Imran Farhat and Mohammad Hafeez, who did the job in Pakistan's last Test at The Oval, and also Shoaib Malik who missed the series against England.
Samiullah is drafted into the squad following the suspensions handed down to Shoaib Akhtar and Mohammad Asif. He toured England but was granted limited opportunities. However, he has been in outstanding form domestically at the start of the season.
Inzamam-ul-Haq, who is serving his four-match ODI ban, will lead the side. West Indies arrive in Lahore on Monday night, where the first Test starts on November 11, followed by Multan on November 19.
Pakistan squad Imran Farhat, Mohammad Hafeez, Yasir Hameed, Younis Khan, Mohammad Yousuf, Inzamam-ul-Haq (capt), Faisal Iqbal, Shoaib Malik, Abdul Razzaq, Kamran Akmal (wk), Danish Kaneria, Samiullah Khan, Shahid Nazir, Abdul Rehman, Umar Gul.