Durham 277 and 28 for 2 lead Warwickshire 197 (Rushworth 5-46) by 108 runs
Durham's Chris Rushworth produced his second career-best performance of the week as Warwickshire's Championship challenge faltered at Chester-le-Street.
Brought in as a replacement for Graham Onions, 25-year-old Rushworth followed his one-day best of 5 for 31 against Nottinghamshire on Sunday by taking 5 for 46. After an opening stand of 61 Warwickshire were all out for 197, trailing by 80, and Durham reached 28 for 2 in their second innings.
Rushworth's previous first-class best was 4 for 90 at Chelmsford in 2010 and this is only his second Championship appearance in the last season and a half. Resuming on 228 for 5, the day began badly for Durham when Paul Collingwood was out to the first ball. He played forward and the ball from Chris Woakes went through to Tim Ambrose.
Collingwood appeared to query Steve Garrett's decision and the umpire indicated he was lbw. It sparked the loss of five wickets for 49 runs and Durham were all out for 277. Three of the last four fell to catches at second slip by Rikki Clarke, giving him five in the innings, and there were four wickets each for Woakes and Keith Barker.
Acting captain Varun Chopra and Ian Westwood began very cautiously for Warwickshire, scoring only 30 in the first 20 overs. Rushworth had four confident lbw appeals turned down as he conceded only one run in his first six overs, while left-armer Jamie Harrison's first nine overs cost only 13.
The breakthrough came in Steve Harmison's second spell when left-hander Westwood slapped the second ball, a long hop, straight to Collingwood at cover. Collingwood then returned to second slip and caught Will Porterfield, who edged an airy drive at Ben Stokes.
Chopra departed for 29 when he was caught down the leg side by Mustard off Harmison, then Rushworth removed Darren Maddy and Clarke in successive overs to leave Warwickshire rocking on 90 for 5. While Tim Ambrose dug in, Woakes made 29 before becoming the second batsman to be strangled down the leg side, then Stokes sent Barker's middle stump flying.
Rushworth returned to take the last three, leaving Durham with 11 overs to bat. They were in the sixth when Mark Stoneman was adjudged lbw to a swinger from Barker, then Woakes got one to skid on and pin Will Smith in front. Harrison, acting as nightwatchman for the second successive day, survived the last three overs with Gordon Muchall.