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Southern Vipers 166 for 7 (Wyatt 54, Beaumont 53, Taylor 40, Hartley 2-34) beat Lancashire Thunder 132 (Boyce 43, Farrant 3-18, Wyatt 2-14, Bell 2-19) by 34 runs
Beaumont smashed five sixes in her 53 off 33 balls, including three in as many balls, as the Vipers posted an imposing 166 for 7 after having elected to bat. Beaumont's first game as captain after taking over from Suzie Bates saw the 2016 champions fly out of the blocks as opener Wyatt hit ten fours in her 54 off 39 balls against her former side, while the dangerous Stafanie Taylor hit a late 25-ball 40.
In reply, Thunder opener Georgie Boyce hit a bright 43, but Wyatt's offspin returned 2 for 14 from three overs, doubling her tally of career KSL wickets, as the hosts were bowled out for 132.
Lancashire, who lost by 34 runs, will rue erring in line and length all too often with the ball on a true pitch. Kate Cross, who actually struck early to remove Bates, used eight bowlers on her captaincy debut, with only England team-mate Sophie Ecclestone able to offer any real control with her left-arm spinners. Another left-arm spinner, Alex Hartley, claimed two wickets but was expensive.
Wyatt and Beaumont, England's opening pair in T20Is, shared 100 in 10.3 overs to advance from 8 for 1 in the second. Both were particularly punishing on anything short and wide. Wyatt was first to 50 off 33 balls before, in the 11th over, Beaumont moved to 50 off 23 with three successive sixes off seamer Cross. Sophia Dunkley later took a superb return catch to remove Beaumont in an attempt to stymie progress.
Beaumont further stamped her authority on the game early in the Thunder chase when she took a good high catch in swirling wind at midwicket to help seamer Lauren Bell remove Sune Luus, leaving the score at 11 for 1 in the fourth over.
Boyce and Tahlia McGrath both hit sixes as 32 then came off the medium pace of Bates and the legspin of McGrath's Adelaide Strikers team-mate Amanda Wellington in the ninth and tenth overs to take the hosts to 65 for 1 at the halfway mark.
But Wyatt's offspin claimed the scalp of McGrath in the 11th, caught at long-on, as the score fell to 68 for 2. She struck again in the 13th to get Harmanpreet Kaur stumped by Carla Rudd for 1 before wickets fell in a hurry in a forlorn pursuit of quick runs and the victory target.
Boyce was one of those, while Wyatt also added a catch to rubber-stamp her memorable day. Tash Farrant finished 3 for 18.
Both sides are next in action on Thursday - the Vipers travel to Loughborough and the Thunder take on champions Surrey at Guildford.