Lancashire 306 and 240 for 4 beat Nottinghamshire 326 and 216 by six wickets
Stephen Moore's first County Championship hundred for Lancashire secured a six-wicket victory for the title chasers and condemned defending champions Nottinghamshire to their fourth straight defeat.
Needing 237 on a tricky pitch with variable bounce, Moore's determined and gutsy unbeaten 124 from 208 balls carried the visitors home in 74 overs and pushed them to within seven points of leaders Durham.
Moore was granted one extra life on 57, when his attempted cut off Paul Franks to deep backward point was spilled by Riki Wessels, and the 30-year-old went on to seal the win with his 17th four.
Despite Charlie Shreck's 3 for 54, Nottinghamshire never threatened to find the 10 wickets they needed to end their terrible run of form - which has seen them fail to claim a win since the end of April - and they appear destined to spend the second half of the season battling to avoid relegation rather than challenging to retain the title.
Resuming their second innings on 32 without loss, Lancashire openers Moore and Paul Horton showed good judgment outside off stump to survive the opening half-hour before a swinging delivery from Shreck tempted Horton to drive and edge to David Hussey at second slip for 30.
Karl Brown then fell lbw to Shreck eight overs later but Moore went on to share a 90-run partnership for the third wicket with Mark Chilton as Notts became increasingly frustrated in the field.
Wessels' drop shortly after lunch appeared crucial as Moore's batting grew in assurance, with the former England Lions batsman pulling Luke Fletcher for six shortly before Andre Adams had Chilton lbw for 35.
By then Nottinghamshire seemed to have resigned themselves to defeat, with little innovation in field placements from captain Chris Read as the hosts went through the motions in the closing stages.
Moore, driving and cutting with power, secured his first century since July 2009 with a cut for four off Shreck to the sound of generous applause from the Lancashire dressing room. And although Steven Croft gave Hussey another slip catch off Shreck with 11 more runs needed, nothing could stop Moore and Lancashire from claiming the win.
The only black spot for the visitors was the docking of one point for their slow over-rate, but they will view their first Championship win at Trent Bridge since 2006 as more than adequate compensation.
Notts vs Lancashire
England Domestic Season
County Championship Division One