Steven Finn has been ruled out of the World T20 in India with a calf strain with Liam Plunkett named as his replacement.
It is the latest blow for Finn who has suffered an injury-hit period. He was forced out of the tour of the UAE before Christmas with a stress injury to his left foot and left the tour of South Africa early with a side strain he picked up during the third Test in Johannesburg.
"He was just warming up for a bowl a couple of days ago and felt his calf go ping," Angus Fraser, Middlesex's director of cricket, told ESPNcricinfo. "He had the scan today and unfortunately we can't take him. I've just spoken to him and he's pretty low at the moment."
In between his injuries, Finn has developed into an automatic pick for England in all three formats, and the absence of his hostile method of attack on India's wickets will be a major dent to England's hopes of progressing deep into the tournament.
He has endured a bittersweet period in the past six months, having fought back from being deemed "unselectable" during the 2013-14 Ashes to claim eight wickets on his return to Test cricket last summer. Against Australia at Edgbaston last July, he claimed a second-innings haul of 6 for 79 in his first outing for two years.
"Really disappointed to have picked up another injury on my road to recovery," Finn tweeted. "Gutted doesn't describe it. Good luck to the guys out there!"
Plunkett was considered unlucky not to make the original 15-man squad, having impressed in the T20 series against Pakistan in the UAE. He claimed three wickets in each of his two appearances in England's 3-0 series win, including a decisive haul of 3 for 33 in a three-run win in the second match at Dubai.
Plunkett will now form England's pace options for the tournament alongside David Willey, Reece Topley, Chris Jordan and Ben Stokes.