Lancashire 119 and 284 (Buttler 72, Smith 54, Stone 4-65) beat Northamptonshire 164 (Spriegel 62, Anderson 5-48) and 179 (Middlebrook 87, Anderson 5-41) by 60 runs
James Anderson completed a 10-wicket match as Lancashire sealed a 60-run win over Northamptonshire in their first match without Peter Moores at the helm.
Moores has already started work as England head coach and will be thankful to have Anderson at his services in that role, as the seamer claimed the first two wickets on the final morning at Wantage Road to tee up victory and finish with combined figures 10 for 89.
Northamptonshire resumed on the fourth morning 145 for 5 with 95 still to get but instead mustered only 34 as the visitors finished the job in just 15 overs.
James Middlebrook, 78 not out overnight, resumed alongside Ben Duckett, with Anderson beginning alongside skipper Glen Chapple. The former got Lancashire going with the second ball of his third over, snapping up a low return catch off Duckett's leading edge to send him back for 26.
Just two runs were added before Anderson struck again, former team-mate Steven Crook attempting to pull a short ball from outside off stump only to be caught by Luke Procter at mid-on.
That allowed Anderson to finish with 5 for 41 to go with his first-innings effort of 5 for 48, a statement of intent ahead of the international programme.
Northamptonshire retained a theoretical chance as long as Middlebrook remained but when he drilled Chapple to the waiting Ashwell Prince for 87, the result was all but settled. Kabir Ali applied the finishing touch, accounting for Olly Stone and Azharullah to close with 3 for 17 as Lancashire banked 19 points.
Off the field, Lancashire announced the appointment of former club captain Mark Chilton to the coaching staff. Although Chapple has taken an expanded leadership role in Moores' absence, a vacancy behind the scenes was still created and Chilton, who retired in 2011, will be a popular choice at Old Trafford.
Director of cricket Mike Watkinson said: "Following the recent changes in our coaching structure, it was vital that we had some continuity to enable us to carry on our progress.
"He has demonstrated his leadership skills in his role of club captain and he will have a great influence on the squad. He is Lancashire through and through and had a successful career at Emirates Old Trafford. He hasn't been out of the first-class game for long and is in touch with the requirements of the modern day cricketer."
Chilton added: "I am thrilled at the prospect of returning to Lancashire. We have an exciting crop of emerging young players and I am looking forward to working with them."